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A police officer and a rescue worker walk in front of the remains of Ria Pizza restaurant in Kramatorsk © AP

Two Russian S-300 missiles struck the eastern Ukrainian city of Kramatorsk on Tuesday evening, killing two people and destroying a popular pizzeria and shopping centre, according to regional authorities.

One missile struck near Hotel Kramatorsk, turning Ria Pizza and other businesses into rubble, videos posted by local officials and residents on Telegram showed. 

Ihor Klymenko, Ukraine’s interior minister, said in a statement that at least two people had been killed and 22 injured, including a child. Several people could be trapped under the resulting rubble.

The missiles struck Kramatorsk at about 7.30pm local time. The city sits approximately 20km from the frontline in eastern Ukraine and is a crucial garrison town, making it a regular target for Russian attacks.